Valproic Acid and sodium valproate: comprehensive profile.
نویسندگان
چکیده
منابع مشابه
Evaluation of Liver Enzymes Rising in Patients Treated with Sodium Valproate (VPA)
Introduction Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity. The aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of VPA treatment and after three and six months of it. Materials and Methods This study was designed as a cross sectional pro...
متن کاملPreparation of Coated Valproic Acid and Sodium Valproate Sustained-release Matrix Tablets
The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on drug release from valproic acid-sodium valproate matrix tablets prepared with w...
متن کاملSodium Valproate in Childhood Epilepsy
As the brand Epilim, there is a sugar free liquid and oral syrup both containing sodium valproate 200mg in 5ml. It is also available as sodium valproate 100mg crushable tablets, 200mg and 500mg enteric coated tablets and 200mg, 300mg and 500mg modified release tablets. There are also a number of these preparations available as generic formulations both of sodium valproate and valproic acid. It ...
متن کاملPancreatitis during sodium valproate treatment.
A girl aged 1 year died of acute haemorrhagic pancreatitis while taking sodium valproate. Necropsy showed widespread vascular disease that may have contributed to the onset of pancreatitis. Previous reports of pancreatitis in children receiving valproic acid are reviewed and although the association is rare, a causal relation between pancreatitis and valproic acid seems to have been established.
متن کاملAssessment of Dissolution Profiles of Brand and Generic Valproic Acid Formulations Based on an Experimental Clean Automatic Approach
Several commercial brand and generic formulations containing sodium valproate (NaVA) alone or in different combinations of this with valproic acid (VAac) were assayed using a clean automatic approach. To accomplish it, a sequential injection analysis based system coupled to potentiometric detection was exploited. The dissolution tests were performed at pH 6.8 where valproic acid (VAac) is quant...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Profiles of drug substances, excipients, and related methodology
دوره 32 شماره
صفحات -
تاریخ انتشار 2005